' 
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 7 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
Folate treatment aids liver fat reduction
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner.
Direct focus on NAFLD treatment
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
Read More
3
Folate treatment shows limited benefits
Folic Acid and Methyltetrahydrofolate Supplementation in the Mouse Model with Hepatic Steatosis.
Study focuses on liver disease
We explored the impact of two forms of folate—methyltetrahydrofolate (methylTHF) and folic acid—on liver health in a specific mouse model that presented genetic variations affecting folate metabolism. Through our study, we compared mice with different MTHFR genotypes and assessed how these supplements influenced conditions like hepatic steatosis, which is essentially fat buildup in the liver.
Mice were divided into groups and fed diets that either contained regular food, supplemented with methylTHF, or enriched with folic acid for four months. Following this period, we examined the livers of these mice for signs of liver disease and checked important metabolites related to one-carbon metabolism, which is crucial for numerous bodily functions.
The results were quite revealing. Both forms of folate showed limited effectiveness against liver fat accumulation in the mice with the 677TT genotype. In fact, while methylTHF supplementation did not significantly alter plasma homocysteine levels or liver fat in either gender, folic acid supplementation seemed to have negative consequences for the liver of female mice with the 677CC genotype.
Overall, our findings indicate that folate treatment, whether via methylTHF or folic acid, did not provide substantial benefits for mice predisposed to liver disease due to their genetic makeup. Further investigation would be necessary to see if these findings apply to humans.
Mice were divided into groups and fed diets that either contained regular food, supplemented with methylTHF, or enriched with folic acid for four months. Following this period, we examined the livers of these mice for signs of liver disease and checked important metabolites related to one-carbon metabolism, which is crucial for numerous bodily functions.
The results were quite revealing. Both forms of folate showed limited effectiveness against liver fat accumulation in the mice with the 677TT genotype. In fact, while methylTHF supplementation did not significantly alter plasma homocysteine levels or liver fat in either gender, folic acid supplementation seemed to have negative consequences for the liver of female mice with the 677CC genotype.
Overall, our findings indicate that folate treatment, whether via methylTHF or folic acid, did not provide substantial benefits for mice predisposed to liver disease due to their genetic makeup. Further investigation would be necessary to see if these findings apply to humans.
Read More
8
Folate influences liver cancer survival
Genetic variants in folate metabolism-related genes, serum folate and hepatocellular carcinoma survival: the Guangdong Liver Cancer Cohort study.
Directly examines folate impact
We explored how genetic variations in folate metabolism might influence survival rates in patients with hepatocellular carcinoma (HCC), a common form of liver cancer. Our study involved a large group of 970 HCC patients who provided genetic information on six specific single nucleotide polymorphisms (SNPs). We further looked at the relationship between these genetic factors and serum folate levels to understand their combined impact on overall survival and liver cancer-specific outcomes.
Interestingly, we found that a particular SNP known as rs1801394 showed a significant connection with better survival rates. In various models, including additive, co-dominant, and dominant types, carrying the G allele of this SNP was linked to improved overall survival. We also noticed that the more protective alleles a person carried, the better their liver cancer-specific survival and overall survival became.
Moreover, we observed that having higher levels of serum folate interacted positively with this genetic variant, enhancing the prognosis for those carrying the G allele. This suggests a promising link between folate metabolism and liver cancer outcomes, highlighting the importance of genetic factors in how folate may affect survival in liver disease patients.
Interestingly, we found that a particular SNP known as rs1801394 showed a significant connection with better survival rates. In various models, including additive, co-dominant, and dominant types, carrying the G allele of this SNP was linked to improved overall survival. We also noticed that the more protective alleles a person carried, the better their liver cancer-specific survival and overall survival became.
Moreover, we observed that having higher levels of serum folate interacted positively with this genetic variant, enhancing the prognosis for those carrying the G allele. This suggests a promising link between folate metabolism and liver cancer outcomes, highlighting the importance of genetic factors in how folate may affect survival in liver disease patients.
Read More
Most Useful Reviews
6.8
Reduced homocysteine
Methylfolate is an effective, active form of folate, essential due to the body’s limited ability to convert synthetic folic acid. It helps lower homocysteine levels linked to cardiovascular diseases. It's best taken alongside vitamins B12 and B6. Highly recommend this supplement as one of the best available.
Read More
9.5
Supports liver function
Methylfolate is an easily absorbed, active form of folate that is essential, especially for women during pregnancy. It aids liver function and detoxification, while positively influencing my skin and hair. I take it due to folate cycle mutations and use it alongside B12 for better absorption. Dosage varies based on B9 levels and mutation type. I take it with food, but it's also fine on its own.
Read More
9
Enhanced recovery
I find Jarrow Formulas’ folic acid excellent. Vitamin B9 is vital, helping with energy, mood stability, and food absorption. It’s especially important for those with liver disease. This supplement is top quality, containing 5-methyltetrahydrofolate. The 400 mcg dosage tastes good and can be taken with meals.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
- All Researches
9
Folate treatment aids liver fat reduction
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner.
Direct focus on NAFLD treatment
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
Read More
8
Folate influences liver cancer survival
Genetic variants in folate metabolism-related genes, serum folate and hepatocellular carcinoma survival: the Guangdong Liver Cancer Cohort study.
Directly examines folate impact
We explored how genetic variations in folate metabolism might influence survival rates in patients with hepatocellular carcinoma (HCC), a common form of liver cancer. Our study involved a large group of 970 HCC patients who provided genetic information on six specific single nucleotide polymorphisms (SNPs). We further looked at the relationship between these genetic factors and serum folate levels to understand their combined impact on overall survival and liver cancer-specific outcomes.
Interestingly, we found that a particular SNP known as rs1801394 showed a significant connection with better survival rates. In various models, including additive, co-dominant, and dominant types, carrying the G allele of this SNP was linked to improved overall survival. We also noticed that the more protective alleles a person carried, the better their liver cancer-specific survival and overall survival became.
Moreover, we observed that having higher levels of serum folate interacted positively with this genetic variant, enhancing the prognosis for those carrying the G allele. This suggests a promising link between folate metabolism and liver cancer outcomes, highlighting the importance of genetic factors in how folate may affect survival in liver disease patients.
Interestingly, we found that a particular SNP known as rs1801394 showed a significant connection with better survival rates. In various models, including additive, co-dominant, and dominant types, carrying the G allele of this SNP was linked to improved overall survival. We also noticed that the more protective alleles a person carried, the better their liver cancer-specific survival and overall survival became.
Moreover, we observed that having higher levels of serum folate interacted positively with this genetic variant, enhancing the prognosis for those carrying the G allele. This suggests a promising link between folate metabolism and liver cancer outcomes, highlighting the importance of genetic factors in how folate may affect survival in liver disease patients.
Read More
7
Folate's role in liver disease mortality
Associations of serum folate and vitamin B levels with all-cause mortality among patients with metabolic dysfunction associated steatotic liver disease: a prospective cohort study.
High relevance to liver health
We set out to examine how levels of serum folate and vitamin B are associated with all-cause mortality in individuals suffering from metabolic dysfunction-associated steatotic liver disease (MASLD). The data for our analysis came from the Third National Health and Nutrition Examination Survey, which allowed us to follow up on participants over a span of more than 20 years.
Our findings are quite revealing. We discovered that lower serum folate and vitamin B levels are linked to a higher risk of dying from any cause among patients with MASLD. Specifically, when serum folate concentrations fell below a certain threshold, the risk of all-cause mortality noticeably increased. Interestingly, there seemed to be an optimal level of these nutrients, where having more than this amount did not further decrease mortality risk.
In our more detailed analysis, we found that individuals with vitamin B levels in the third and fourth quartiles had a significantly reduced risk of all-cause mortality compared to those in the lowest quartile. Similarly, higher folate levels also appeared to offer some degree of protection. These insights suggest that maintaining healthy levels of folate and vitamin B might be crucial for those dealing with liver disease.
Overall, this research highlights the importance of proper nutritional management in liver health, emphasizing the need for adequate folate and vitamin B intake as part of a comprehensive approach to care in MASLD patients.
Our findings are quite revealing. We discovered that lower serum folate and vitamin B levels are linked to a higher risk of dying from any cause among patients with MASLD. Specifically, when serum folate concentrations fell below a certain threshold, the risk of all-cause mortality noticeably increased. Interestingly, there seemed to be an optimal level of these nutrients, where having more than this amount did not further decrease mortality risk.
In our more detailed analysis, we found that individuals with vitamin B levels in the third and fourth quartiles had a significantly reduced risk of all-cause mortality compared to those in the lowest quartile. Similarly, higher folate levels also appeared to offer some degree of protection. These insights suggest that maintaining healthy levels of folate and vitamin B might be crucial for those dealing with liver disease.
Overall, this research highlights the importance of proper nutritional management in liver health, emphasizing the need for adequate folate and vitamin B intake as part of a comprehensive approach to care in MASLD patients.
Read More
7
MDCs and protective role of folate
Impact of metabolism-disrupting chemicals and folic acid supplementation on liver injury and steatosis in mother-child pairs.
Limited separation of folate effects
In our examination of the relationship between metabolism-disrupting chemicals (MDCs) and liver health, we aimed to understand how these chemicals during pregnancy could potentially affect liver conditions in mothers and their children. We studied around 200 mother-child pairs from the Mexican PROGRESS cohort, measuring levels of various MDCs and assessing liver enzyme activity in children about nine years after birth.
Our findings revealed that exposure to MDCs during pregnancy might raise the risk of liver injury and conditions like steatosis, particularly in children. However, we also discovered that adequate folic acid (FA) supplementation in mothers could reduce these negative effects. This suggests that folic acid might play a protective role against liver health issues tied to environmental pollutants.
By linking MDC exposure with liver health outcomes, particularly in children, we shed light on the importance of maternal health during pregnancy. This research could influence policies aimed at reducing environmental pollution and guide clinical strategies to address liver-related health problems stemming from chemical exposure.
Our findings revealed that exposure to MDCs during pregnancy might raise the risk of liver injury and conditions like steatosis, particularly in children. However, we also discovered that adequate folic acid (FA) supplementation in mothers could reduce these negative effects. This suggests that folic acid might play a protective role against liver health issues tied to environmental pollutants.
By linking MDC exposure with liver health outcomes, particularly in children, we shed light on the importance of maternal health during pregnancy. This research could influence policies aimed at reducing environmental pollution and guide clinical strategies to address liver-related health problems stemming from chemical exposure.
Read More
7
Folate intake and NAFLD mortality
Dietary folate intake and all-cause mortality and cardiovascular mortality in American adults with non-alcoholic fatty liver disease: Data from NHANES 2003 to 2018.
Study evaluates folate's effects
We explored the impact of dietary folate intake on mortality rates among American adults suffering from Non-alcoholic Fatty Liver Disease (NAFLD). Our research utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2003 to 2018, focusing specifically on the connection between folate consumption and both all-cause and cardiovascular mortality.
Our findings indicated that greater dietary folate intake is associated with a lower risk of all-cause mortality in adults with NAFLD. However, it’s noteworthy that while higher folate levels appeared to help reduce the overall death rates, they did not show a significant link to reduced cardiovascular mortality.
These results suggest that increasing folate in the diet could potentially improve health outcomes for individuals with NAFLD, though further research is necessary to fully understand the relationship between folate and various mortality causes in these patients.
Our findings indicated that greater dietary folate intake is associated with a lower risk of all-cause mortality in adults with NAFLD. However, it’s noteworthy that while higher folate levels appeared to help reduce the overall death rates, they did not show a significant link to reduced cardiovascular mortality.
These results suggest that increasing folate in the diet could potentially improve health outcomes for individuals with NAFLD, though further research is necessary to fully understand the relationship between folate and various mortality causes in these patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
6.8
Reduced homocysteine
Methylfolate is an effective, active form of folate, essential due to the body’s limited ability to convert synthetic folic acid. It helps lower homocysteine levels linked to cardiovascular diseases. It's best taken alongside vitamins B12 and B6. Highly recommend this supplement as one of the best available.
Read More
9.5
Supports liver function
Methylfolate is an easily absorbed, active form of folate that is essential, especially for women during pregnancy. It aids liver function and detoxification, while positively influencing my skin and hair. I take it due to folate cycle mutations and use it alongside B12 for better absorption. Dosage varies based on B9 levels and mutation type. I take it with food, but it's also fine on its own.
Read More
9
Enhanced recovery
I find Jarrow Formulas’ folic acid excellent. Vitamin B9 is vital, helping with energy, mood stability, and food absorption. It’s especially important for those with liver disease. This supplement is top quality, containing 5-methyltetrahydrofolate. The 400 mcg dosage tastes good and can be taken with meals.
Read More
8.8
Normalised health
Methylfolate is an excellent form of folic acid. Vitamin B9 is crucial for blood formation, and after taking it, my anaemia improved. I take 800 mcg daily in the morning, separately from B6, B12, and zinc. B9 has been effective in treating stubborn anaemia that iron or B12 couldn’t resolve. It also benefits liver health. During pregnancy, the need for vitamin B9 increases significantly. If my review was helpful, please like it. Wishing everyone good health!
Read More
8.8
Restored health
Methylfolate is a superb form of folic acid. Vitamin B9 is essential for blood formation, and my anaemia improved after taking it. I take 800 mcg each morning with meals, avoiding B6, B12, and zinc with it. B9 is effective against stubborn anaemia that doesn't respond to iron or B12 and is beneficial for the liver. The demand for B9 increases during the first and third trimesters of pregnancy. If my review was helpful, please like it.
Read More
